Synergistic antiproliferative effect of recombinant interferon-gamma with recombinant interferon-alpha on chronic myelogenous leukemia hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM)
نویسندگان
چکیده
منابع مشابه
Loss of hematopoietic progenitor cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the acquired immunodeficiency syndrome (AIDS)?
Hematological abnormalities have been found in the majority of patients with AIDS, in addition to immunological derangements [1]. Furthermore, treatment of opportunistic infections with folic acid antagonists and of neoplasms with cytostatic drugs is frequently complicated by profound thrombocytopenia, neutropenia, and anemia, thus resulting in the withdrawal of the drugs. In the present study ...
متن کاملEffects of Recombinant a and ‘y Interferons on the In Vitro Growth of Circulating Hematopoietic Progenitor Cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) From Patients With Myelofibrosis With Myeloid Metaplasia
Myeloflbrosis with myeloid metaplasia (MMM) is a chronic myeloproliferative disorder due to clonal expansion of a pluripotent hematopoietic progenitor cell with secondary marrow fibrosis. No definitive treatment has as yet been devised for this condition, which shows a marked variability in clinical course. To evaluate whether excessive hematopoietic progenitor cell proliferation could be contr...
متن کاملSynergistic Antiproliferative Effect of Recombinant Interferon-’y With Recombinant Interferon-a on Chronic Myelogenous Leukemia Hematopoietic
Recombinant interferons, a (rlFN-a) and ‘y (rIFN-’y), have been demonstrated to have significant antitumor activity as single agents in the treatment of chronic myelogenous leukemia (CML). Due to their possible synergistic efficacy. a combination rIFN therapy in CML has been proposed. To establish a biologic basis for this, we have studied the suppressive effects of rIFN-a and rlFN-’y on the in...
متن کاملTreatment with Interferon- a Preferentially Reduces the Capacity for Amplification of Granulocyte-Macrophage Progenitors (CFU-GM) from Patients with Chronic Myeloid Leukemia but Spares Normal CFU-GM
The biological target for interferon (IFN)a in chronic myeloid leukemia (CML) is unknown, but one possibility is that amplification of granulocyte-macrophage colony-forming cells (CFU-GM) is reduced. Replating CFU-GM colonies and observing secondary colony formation provides a measure of CFU-GM amplification. Amplification of CML, but not normal, CFU-GM in vitro was significantly inhibited by I...
متن کاملErythroid progenitors (BFU-e and CFU-e) in acute leukaemia.
Bone marrow erythroid progenitor cells were examined from 50 cases of acute leukaemia and from 20 normal subjects using an in vitro semisolid culture method. Numbers of both primitive erythroid progenitor cells (BFU-e) and later-stage erythroid progenitor cells (CFU-e) were remarkably depressed in patient with acute leukaemia in active phase. However, both BFU-e and CFU-e recovered to within no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1988
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v72.4.1293.bloodjournal7241293